mRNA splicing is a fundamental part of the process ... might be treated by repositioning the normal copy of the gene for that ...

Research into splicing mechanisms and patterns is essential for decerning fundamental biological principles, as well as clarifying the molecular basis of many diseases and developing new therapies. 2 ...

Heidelberg biochemists and structural biologists from Shanghai unravel the roles of two key regulatory factors in mRNA ...

Splicing does more than it was initially cut ... During translation of normal mRNA, Y14 (located upstream of exon–exon junctions) would be removed. As the termination codon of higher eukaryotes ...

RT-PCR and sequencing revealed a small amount of normal-size mRNA with normal exon 1-exon 2 splicing. Quantitative RT-PCR on mutant LMSF showed AR mRNA levels were well below 10% of normal ...