Researchers in Japan found that estrogen produced within the brain, called neuroestrogen, suppresses appetite and reduces ...

A knockout mouse is a laboratory mouse in which one or more genes have been turned off or "knocked out." To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene ...

These heart cells rupture and leak DNA, which sparks a damaging immune response. This breakthrough challenges long-held assumptions and offers fresh strategies for preventing heart failure by calming ...

“In light of these findings, published studies involving immune or hematopoietic phenotypes in which these C57BL/6 mice have been used as controls, as experimental animals, or for backcrossing will ...

enabling researchers to create thousands of strains of genetically altered mice. Smithies’ colleagues remembered him as an adept motivator, able to inspire in others the same passion that marked his ...

However, because so many mouse genes are similar to human genes, geneticists can generate knockout mice in which the mouse counterpart of a human gene of interest is deleted or disrupted.

Metabolic dysfunction-associated steatotic liver disease (MASLD), is the most common form of chronic liver disease worldwide. This study aimed to explore the role of TM6SF2 in high-fat diet ...

Estrogens are known for their role in reproduction, but a new study from Fujita Health University, Japan, reveals that ...

The three key functions of the Core are listed below: These CF mouse models produce no functional Cftr mRNA or protein, and are particularly useful to stufy consequences of the electrophysiological ...

The Knockout Mouse Phenotyping Program (KOMP2) sites at Baylor College of Medicine, Jackson Laboratory, and University of California, Davis, are collaborating with the International Mouse Phenotyping ...