More information: Andrew Brennan et al, An Intracellular Peptide Library Screening Platform Identifies Irreversible Covalent Transcription Factor Inhibitors, Advanced Science (2025). DOI: 10.1002/advs ...

As a reversible inhibitor, harmine temporarily binds to monoamine oxidase A, allowing the enzyme to function again once ...

Conclusion: Rasagiline is an investigational selective and irreversible inhibitor of MAO-B that has demonstrated efficacy and safety for the treatment of PD. Whether rasagiline is associated with ...

The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation ... By applying a second inhibitor (flavopiridol) that blocks the activity of Cdk ...