An irreversible inhibitor causes covalent modification of the enzyme, so that its activity is permanently reduced. Compounds that act as irreversible inhibitors are often useful as drugs that need be ...
The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation ... By applying a second inhibitor (flavopiridol) that blocks the activity of Cdk ...
Key enzyme can be inhibited The enzyme LpxC, which catalyzes the first irreversible step in the ... the cellular response to ...