which may allow classification into functional subgroups based on signaling pathways. Members of the TREM family of innate immune proteins function as 'amplifiers' of innate responses and as ...

"Living organisms have evolved complex pathways to sense, signal, and repair damaged DNA," he says. "Here we're learning new things about the role of the innate immune system in responding to that ...

E.H. Sklan, P. Charuworn and P.S. Pang declared no competing interests. Innate immune signaling pathways interdicted by HCV. HCV interferes with numerous defense mechanisms, including virus ...

Innate Immune Response: The body's first line of ... cGAS-STING Pathway: A signaling pathway activated by cytosolic DNA that leads to the production of type I interferons and plays a role in ...

The common and important infectious viruses in pigs and poultry mainly include DNA and RNA viruses, which pose significant threats to both animal and human ...

A Potential Therapeutic Target for Steroid Resistant Asthma,” published in the December 2024 issue of Allergy and Immunology ...

The Alexander Gitlin Lab studies how inflammatory cell signaling controls the nature and magnitude of inflammation under physiological and disease conditions. Innate immune cells are ... decipher ...

A research team at Memorial Sloan Kettering Cancer Center (MSK) has made new insights into how the body forms immune cell ...

We found that G3BP1 nucleation of stress granules activates PKR, resulting in phosphorylation of eIF2alpha and activation of NF-kB and IFN signaling pathways. This demonstrates that cellular stress ...

This study unveiled the role of Lrrk2 gene in regulating macrophage polarization and immune response. This finding provides ...

We found that tumor-resident cytotoxic type 1 innate lymphoid cells (ILC1s ... their CTL suppressor function titratable along the PI3K-Akt-Foxo1 signaling pathway to overcome cancer immune tolerance ...