Congenital heart disease (CHD) is one of the most common birth defects, but the full extent of its genetic underpinnings has ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies ...

The beads are called nucleosomes. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed ...

Now, Warnecke and colleagues are challenging the idea that these space-saving proteins are not commonplace in bacteria. In a preprint uploaded to bioRxiv this January that has yet to undergo peer ...

Novel technology enables discovery, which could help predict tumour recurrence Researchers from the Fred Hutch Cancer Centre, ...

Proteins, much like the rest of the body, change when aging. This is especially the case for the histone proteins that make up chromatin, which may "live" for ~100 days before being replenished ...

Researchers from the University of Colorado Cancer Center have solved a cellular mystery that may lead to better therapies ...

They discovered that despite relatively weak binding by an essential protein—histone variant CENP-A/Cse4—to DNA, other proteins are recruited to one specific site in the center of the chromosome ...

Schematic representation of histone-modifying factor recruitment on cccDNA minichromosomes in relation to viral protein HBx. In the presence of HBx, histone-modifying factors such as p300/CBP, Set1A, ...

Beyond its canonical role in H3K27 trimethylation, EZH2 has been found to regulate non-histone proteins, activating pathways that promote metastasis and chemotherapy resistance. By targeting EZH2 ...