For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of efficacy ...

However, despite decades of study, many aspects of helicase function remain unclear, including the exact mechanics of strand separation, how ATP hydrolysis drives movement, and how helicases ...

Then, a protein known as helicase attaches to and breaks apart the hydrogen bonds between the bases on the DNA strands, thereby pulling apart the two strands. As the helicase moves along the DNA ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors. Drug works similarly to ...