For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the DNA repair enzyme Werner helicase, demonstrated early signals of efficacy ...

However, despite decades of study, many aspects of helicase function remain unclear, including the exact mechanics of strand separation, how ATP hydrolysis drives movement, and how helicases ...

The RF is a multiprotein complex with helicase and DNA synthesis activities. It is called a fork because the structure resembles a two-pronged fork. The helicase activities unwind DNA in front of ...

RO7589831, a new drug from Roche, is first in a new class of drugs called Werner helicase inhibitors. Drug works similarly to ...