Figure 4: H2B ubiquitination of the p21 gene correlates with p53-dependent transcriptional activation. (a) H1299-tsp53 cells, harbouring a temperature sensitive p53 mutant, ...

A research team has recently made a significant breakthrough in understanding how the DNA copying machine helps pass on epigenetic information to maintain gene traits at each cell division ...

H2B.8-mediated condensation is sufficient for immotile sperm and compatible with gene activity." ... Histone H2B.8 compacts flowering plant sperm through chromatin phase separation. Nature, ...

Specifically, the researchers were interested in specific acetylations on the histone H3–H4 complex to which p300/CBP binds. These acetylations are known to activate gene expression in nearby DNA ...

“We demonstrate an exciting new mechanism of genome compaction that does not compromise gene activity.” Histone H2B.8 compacts flowering plant sperm via chromatin phase separation, appears in ...