p53 recruits enzymes that modify histones to regulate gene expression. To investigate the role of p53, Oren says that they “wanted to perform [ChIP] to determine the extent of histone H2B ...

Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional ...

precisely regulate gene expression by dynamic remodeling of chromatin. Eukaryotic DNA is wrapped around a histone octamer (H3/H4 heterotetramer and two H2A/H2B dimers) to form the nucleosome, the ...