For example, when we inactivate (knock out) the folate receptor (Forl1) gene-its protein product which is a receptor molecule that brings vitamin B9 (folic acid) into cells is eliminated, and the ...

The discovery of the tyrosine kinase Syk, the development of powerful mouse models for pancreatic and colon cancer, and the mechanistic exploitation of the folate receptor, are examples of Purdue ...

AbbVie's $10.1 billion takeover of ImmunoGen has been rewarded with EU approval for Elahere, the first drug specifically cleared for folate receptor-alpha (FRα) positive, platinum-resistant ...

Umoja’s only clinical-stage candidate is UB-TT170, a TumorTag-based treatment that tags solid tumor cells that express folate receptor alpha. The asset is being evaluated in a phase 1 trial ...

The manufacturer, On Target Laboratories, said Cytalux binds to folate receptors and enters tumor cells. It glows a bright neon green during surgery. “In layman’s terms, you’re trying to ...

Strong rationale for use of small molecule drug conjugate in cancers that overexpress the folate receptor, such as ovarian cancer, triple negative breast cancer and non-small cell lung cancer. Team ...