Australian researchers are providing new hope for a cruel killer disease with royal connections. Called mitochondrial disease, it affects as many as one in 2000 Australians and is deadly when it robs ...

For example, when we inactivate (knock out) the folate receptor (Forl1) gene-its protein product which is a receptor molecule that brings vitamin B9 (folic acid) into cells is eliminated, and the ...

which is a receptor that binds folate, a molecule important for normal cell growth and function. Folate receptor alpha is ...

The platform technology will take the form of a small-molecule drug conjugate made of urokinase, folic acid and a linker, which will then activate prodrugs in the proximity of tumours. Strong ...

To achieve this, scientists first grafted it to folic acid, a molecule that targets receptors overexpressed in ovarian-derived peritoneal metastases. The photosensitizer thus obtained has been ...

Each PAMAM molecule was subjected to a sequence of chemical modifications (Fig. 1), leading to the subsequent addition of either folate or fluorescein, followed by the addition of a 34-base-pair ...

of folic acid per day by mouth for six to eight weeks, and the aspiration repeated. Marrow specimens were stained by the Jenner–Giemsa technic and viewed with a light microscope. They were ...