Major U.S. stock indexes are poised to open sharply lower on Monday after President Donald Trump over the weekend signed executive orders calling for tariffs to be imposed on Canada, Mexico and China.

The five stocks at the bottom of the barrel, which pulled down the winners, were in fact, losers. Not only were they the tail of a year with growth, but they all lost value over the year. In order of best to worst, the list includes Johnson & Johnson ( JNJ 4.13%), Merck ( MRK 2.50%), Amgen ( AMGN 2.73%), Nike ( NKE 2.73%), and Boeing ( BA -0.51%).