To prevent this, cells import the amino acid cystine, which helps in the formation of glutathione, a potent antioxidant that can counteract lipid peroxidation. Without enough cystine, lipid ...

a metabolite known to foster cancer cell proliferation. Moreover, the bacterium modulated the cystine/glutamate antiporter, boosting its activity to enhance bacterial infection and promote ...

a metabolite known to foster cancer cell proliferation. Moreover, the bacterium modulated the cystine/glutamate antiporter, boosting its activity to enhance bacterial infection and promote ...

Ferroptosis was first identified in RAS-mutant cancer cells exposed to erastin and related compounds, which inhibit the cystine/glutamate antiporter (system Xc-) and impair GSH synthesis.