Medications play a crucial role in controlling ... Anticoagulants interfere with the clotting cascade, a series of events ...

factors in the clotting cascade, patients have an increased risk of bleeding with invasive procedures. Patients also have an increased risk of developing a thromboembolism if these drugs are ...

However, prescription medications are quite common ... and expression of a tissue factor that initiates the coagulation ...

without affecting other elements of the clotting cascade that can lead to bleeding side effects. TargED intends to go after aTTP in its initial clinical development programme for the new drug, but ...

So far, one aptamer drug that binds to vascular endothelial ... secondary structures and targets in the coagulation cascade (factor IXa and factor Xa) could both be inactivated by protamine.