These chromatin packing domains are critical for regulating gene expression, DNA replication and preventing DNA damage. While it's well known that DNA processes are disrupted in cancer, ...

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.

“Genes are like hardware, and chromatin is software,” Vadim Backman, the co-senior author of the study, explained in a statement. “And chromatin packing is the operating system.” ...

Chromatin protective drugs used to treat heart disease and arthritis prevent chemotherapy resistance developing in multiple cancer cell lines tested. genprowebdirectory ...

Packaging of DNA can be tighter or looser in different regions of chromatin. While a loose packaging indicates an "active" or a gene "ON" region, a tight compaction means a "silent" or a gene "OFF ...

Abnormal chromatin packing drives cancer cells' ability to do this." The study will be published on Jan. 8, 2020 in the journal Science Advances.

They used PWS to monitor chromatin in cultured cancer cells. They found that chromatin has a specific “packing density” associated with gene expression that helps cancer cells to evade treatments.

Chromatin is responsible for packing DNA into the cell nucleus. In humans, that's about six feet of DNA in each cell. The new work suggests that chromatin is more structured and hierarchical in ...

Using a technique called Partial Wave Spectroscopic (PWS) microscopy, they analyzed cancer cells’ chromatin structure in real-time. In contrast to healthy cells, cancer cells adopted a chromatin ...

These chromatin packing domains are critical for regulating gene expression, DNA replication and preventing DNA damage. While it's well known that DNA processes are disrupted in cancer, ...

Made of DNA, RNA, and proteins, chromatin determines which genes get suppressed or expressed. In the case of cancer, chromatin can regulate expression of the genes that enable cells to become ...

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.