Within chromatin, structures called packing domains form when chromatin fibers fold together. These chromatin packing domains are critical for regulating gene expression, DNA replication and ...

Each of us has enough DNA to reach from here to the sun and back, more than 300 times. How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a ...

The scientists observed that chromatin self-organizes into "packing domains"—distinct, compact regions of molecular structures that play a crucial role in regulating gene expression.

Kanazawa University and colleagues have achieved a breakthrough in understanding sperm DNA packaging. Using high-speed atomic ...

A study by scientists at the Herbert Irving Comprehensive Cancer Center (HICCC) introduces a more cost-effective, scalable ...

So, this whole idea of chromatin packing and chromatin folding comes into play, of where are the genes in the cell, and how are they regulated that way,” remarked Cosgrove. “Generally, methylation at ...

Alternatively, packing of sperm chromatin may serve to reprogram the paternal genome so that the appropriate genes from the father's chromosomes are expressed in the early embryo. Whereas most ...

EDINBURGH, Scotland, April 14, 2025 /PRNewswire/ -- Chromatin Bioscience, a leader in the design of synthetic promoters and gene control systems, is pleased to announce a collaboration agreement ...

Beyond cancer detection, these signatures offer insight into subcellular structures, including chromatin packing and organelle organization. Since nanoscale nuclear changes drive genetic alterations ...

My research program is focused on understanding epigenetic mechanisms that govern higher order brain function via chromatin packaging in neurons.