Each of us has enough DNA to reach from here to the sun and back, more than 300 times. How is all of that DNA packaged so tightly into chromosomes and squeezed into a tiny nucleus? Histones are a ...

Alternatively, packing of sperm chromatin may serve to reprogram the paternal genome so that the appropriate genes from the father's chromosomes are expressed in the early embryo. Whereas most ...

Using advanced imaging, sensing, and analysis techniques, researchers discovered that transcriptional memory is encoded in 3D structural elements called nanoscale chromatin packing domains, which ...

This modification draws a protein called MBD6, which regulates chromatin packaging. TET2 releases some of the constraints ...

Specifically, she works on how viruses use these DNA-packaging proteins, also known as chromatin proteins, to manipulate the host to their own ends. The Avgousti Lab is focused on the mechanisms by ...

Dr. Toshio “Toshi” Tsukiyama studies how cells regulate chromatin, the packaging proteins responsible for compressing several feet of DNA inside each cell’s tiny nucleus. This genetic material needs ...