Choline transporters (CHTs) are concentrated at cholinergic nerve terminals at which these sodium-coupled transport molecules deliver the goods to the cytoplasm for subsequent acetylcholine (ACh ...

Choline is an essential nutrient that contributes to the synthesis of membrane phospholipids, the production of the neurotransmitter acetylcholine, and one‐carbon metabolism. Recent studies have ...

Acetylcholine is produced in the nerve endings of cholinergic neurons by the enzyme choline acetyltransferase (ChAT). The action of ChAT is the slowest step in the process of signal transduction ...

The interconnection between choline metabolism, oxidative stress and bioenergetics underscores the global significance of these transport mechanisms as potential targets for therapeutic intervention.