Aug. 13, 2021 — The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The ...
'[M]ethylglyoxal triggers the destruction of BRCA2 protein, reducing its levels in cells.' 'This effect is temporary, but can ...
Women with a BRCA1 or BRCA2 mutation have up to a 72% chance of breast cancer during their lifetime. Normally, the PALB2 gene makes a protein that works with the BRCA2 gene protein to repair ...
The C-Trap approach even works on one of the toughest targets — the BRCA2 protein itself. It is about 10 times the size of RAD51, which makes it difficult to work with. Purified BRCA2 has been ...
DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code. Researchers have long struggled to understand how cancer cells hijack one of these ...
A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...
Marcy Richardson from Ambry Genetics discusses the importance of a new study that assessed the functional impact of thousands of BRCA2 variants, identifying those that may increase cancer risk. What ...
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