Inherited mutations in the gene BRCA2 significantly increase the risk of carriers to breast and ovarian cancers.  BRCA2, a crucial player in the body& | Cancer ...

Most cancer genome studies have focused on mutations in the tumor itself and how such gene variants allow a tumor to grow unchecked. A new study takes a deep dive into inherited cancer mutations ...

Mutations in BRCA2 — a gene known to repair damaged ... Grossman School of Medicine unveils a previously unknown protective mechanism employed by the gene — and how an existing class of ...

Mutations in BRCA1 and BRCA2—tumor suppressor genes ... "This highlights a distinct mechanism of cytotoxicity, where excessive resection, rather than failed DNA repair by homologous ...

A new study led by scientists at NYU Langone Health sheds light on how the major cancer gene BRCA2 determines which cancer cells can be killed by a class of precision cancer drugs called PARP ...

PRRDetect, which was developed by researchers at the University of Cambridge, could one day be used to identify which cancer ...

Mutations in BRCA2—a gene known to repair damaged DNA ... Grossman School of Medicine unveils a previously unknown protective mechanism employed by the gene—and how an existing class of ...

Cells normally use highly accurate mechanisms to fix these breaks, but some cancers—particularly those arising from BRCA1 or BRCA2 mutations, such as certain breast and ovarian cancers—lack this ...

A recent study by Koch and colleagues demonstrates that these seemingly independent mechanisms interact ... challenge the assumption that BRCA1/2 mutation carriers exhibit significant molecular ...