In the August 14 Proceedings of the National Academy of Sciences, Yee Cho and colleagues at the National Institutes of Health, Bethesda, MD, report the use of DNA microarrays to resolve aspects of the ...

LCGC International spoke with Daniel Meston and Dwight Stoll from Gustavus Adolphus College in St. Peter, Minnesota, USA, ...

For each patient's genetic variant, Tang also designed antisense oligonucleotides—short, synthetic DNA strands that bind to and alter RNA or modify protein expression—to target these poison exons and ...

The DNA repair protein MSH3 promotes the growth of CAG expansions in neurons. Knocking it down with an antisense oligonucleotide blocked CAG expansion in HD neurons. The ASO also took down MSH3 in the ...

These informational drugs, known as antisense therapies, chemically modify genetic sequences to reach specific targets and block disease-associated mRNA. Agrawal likens these therapies to “genetic ...

As surprisingly high proportions of eukaryotic genomes are transcribed, with numerous noncoding and antisense RNAs being ... from evolutionarily unrelated DNA is noise, so analysis of cells ...

sequences (as DNA) into the target sequence (see Fig. 2 for guidance). Insert the miR-30 loop sequence between the sense and the antisense sequences and add the appropriate flanking sequences of ...

Takeda is sharpening its oncology focus amid an R&D revamp. Sun Pharma will acquire Checkpoint Therapeutics and an ...