Only recently has the ribosome—one of the oldest molecular machines in evolutionary terms—been recognized as an active ...

and Furuichi et al., revealed that certain viral and eukaryotic mRNAs have a cap — a methylated guanosine residue linked to the 5′ end of mRNA through an inverted 5′ to 5′ triphosphate bridge.

The popularity of mRNA-based therapeutics has surged over the past few years. To ensure the safety of these treatments, scientists need to analyze the characteristics of the manufactured molecules, ...

Alternatively, researchers can also modify the chemical structure of the mRNA cap found at the molecule’s 5’ end. The naturally-occurring cap structure typical in mammalian cells has a ...