The Buffalo Bills entered the 2025 NFL Draft on April 24 with 10 picks over the three-day draft. After several years of having a somewhat muted amount of early draft picks, the 2025 NFL Draft brings a significant opportunity for the Bills and general manager Brandon Beane.

The Buffalo Bills entered the 2025 NFL Draft with 10 selections, and came away with nine players. For a minute, it looked as if the Bills had forgotten that the offense exists. Buffalo used its first five picks to draft defensive players. In the end, six of the nine draftees are on defense (3 CB, 2 DT, 1 DE).