Hampden South is a neighborhood in Denver, Colorado, United States. Much of the land was acquired in the 1860s by homesteader Rufus Clark, who amassed his fortune growing and selling potatoes to the influx of miners looking to make fortunes in the regional gold rush. The neighborhood was annexed by the City of Denver in the 1960s and s…Hampden South is a neighborhood in Denver, Colorado, United States. Much of the land was acquired in the 1860s by homesteader Rufus Clark, who amassed his fortune growing and selling potatoes to the influx of miners looking to make fortunes in the regional gold rush. The neighborhood was annexed by the City of Denver in the 1960s and subsequently developed into a suburban neighborhood.