Uxpanapa is a municipality in the southeastern part of the Mexican state of Veracruz, adjacent to the state of Oaxaca. It is bordered by the municipalities of Jesús Carranza, Hidalgotitlán, Minatitlán, and Las Choapas in Veracruz, as well as Santa María Chimalapa in Oaxaca. It has an area of 2,600 km².